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FOCAL ADHESION ASSOCIATED PROTEIN TYROSINE KINASE PP125FAK
Descriptors Found:
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DeCS
Descriptor
English
:
Focal Adhesion Kinase 1
Descriptor
Spanish
:
Quinasa 1 de Adhesión Focal
Descriptor
Portuguese
:
Quinase 1 de Adesão Focal
Synonyms
English
:
Endogenous Substrate pp120
Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
Protein Tyrosine Kinase 2
p125FAK Protein
Tree Number:
D08.811.913.696.620.682.725.049.500
D12.776.744.493
Definition
English
:
A non-receptor protein
tyrosine
kinase with
PROTEIN PHOSPHATASE 1
regulatory activity that is localized to
FOCAL ADHESIONS
and is a central component of integrin-mediated
SIGNAL TRANSDUCTION
PATHWAYS.
Focal adhesion kinase 1
interacts with
PAXILLIN
and undergoes
PHOSPHORYLATION
in response to adhesion of cell surface
integrins
to the
EXTRACELLULAR MATRIX
. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing
proteins
and helps regulate
CELL ADHESION
and CELL MIGRATION.
History Note
English
:
2006(1986)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50729
Unique Identifier:
D051417
Occurrence in VHL
:
Similar:
DeCS